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Her2 and metastatic breast cancer the her2 protein is an important driver of cell growth and survival Healthcare providers can treat and often cure this cancer if it’s caught early on A pathologist determines her2 status by testing a sample of the metastatic tumor (from a biopsy of the metastases)
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Advanced breast cancer with overexpression and/or amplification of human epidermal growth factor receptor 2 (her2) is a clinically aggressive subtype with poor survival outcomes A common clinical challenge — therapeutic pivot for addressing mutations in esr1 gene and more 1, 2 however, with the introduction of trastuzumab, the survival rates have greatly improved
1 trastuzumab binds to the extracellular domain iv of her2 preventing its.
